Survodutide (BI 456906) is a synthetic dual-agonist peptide engineered to engage the glucagon receptor and the GLP-1 receptor simultaneously. For research teams evaluating multi-receptor metabolic signaling, it offers a glucagon/GLP-1 profile distinct from GLP-1-only and GIP/GLP-1 analogs. Puritide Research supplies Survodutide as a high-purity, research-use-only material, synthesized for in vitro and animal-model work and backed by third-party-verified certificates of analysis so your data rests on consistent, documented quality.
Available Sizes
- ›Survodutide 5mg Vial
- ›Survodutide 10mg Vial
Product Specifications
- Application
- Dual glucagon / GLP-1 receptor pathway research
- Appearance
- Solid, white lyophilized powder in a sealed glass vial
- Chemical Formula
- C192H289N47O61
- CAS Number
- 2805997-46-8
- Molecular Weight
- ~4231.69 g/mol
- Synonyms
- Survodutide, BI 456906, BI-456906, GCGR/GLP-1R dual agonist
- Storage
- Store at ≤25°C, sealed, away from heat, light, and moisture. For extended storage, keep lyophilized and refrigerated or frozen.
What Is Survodutide?
Survodutide (BI 456906) is a synthetic 29-amino-acid peptide designed to interact with two receptor systems: the glucagon receptor (GCGR) and the glucagon-like peptide-1 receptor (GLP-1R). Its sequence is based on glucagon with amino acid substitutions drawn from GLP-1 and exendin-4, and it carries an acylated C18 fatty-acid modification that supports prolonged stability in experimental systems.
In experimental settings, Survodutide is used to study coordinated glucagon and GLP-1 receptor signaling, receptor cross-talk, and downstream intracellular cascades. Its dual glucagon/GLP-1 design distinguishes it from GLP-1-only compounds such as Semaglutide and from GIP/GLP-1 dual agonists, letting researchers examine a different pairing of metabolic pathways.
Present understanding derives from in vitro assays, animal models, and ongoing clinical research. Findings should be interpreted within their experimental context and not treated as established clinical outcomes. Puritide Research supplies Survodutide strictly for laboratory use; it is not approved for human or veterinary application.
Survodutide Mechanism of Action (Research Only)
Survodutide is studied for its ability to engage two receptors involved in metabolic signaling, GCGR and GLP-1R. Unlike single-receptor analogs, it provides a model for investigating coordinated signaling across two interconnected pathways. The mechanisms below reflect observations from biochemical assays, cell-culture studies, and animal models, and should be read strictly in a research context.
Structural Basis
Survodutide is a glucagon-based peptide incorporating substitutions from GLP-1 and exendin-4 and a C18 fatty-acid acylation that promotes reversible albumin binding. In experimental systems this feature is associated with prolonged molecular stability and sustained receptor engagement, making the compound useful for studies of time-dependent dual-receptor signaling.
Glucagon & GLP-1 Receptor Signaling
One focus of Survodutide research is GLP-1 receptor signaling and the intracellular events initiated after receptor engagement, examined alongside glucagon receptor activity rather than in isolation.
The glucagon receptor component is a distinguishing feature. In animal models, GCGR activation has been associated with increased energy expenditure and hepatic lipid handling, and researchers use Survodutide to investigate how glucagon-axis signaling integrates with GLP-1 pathways.
Because Survodutide engages both receptors in the same model, it is frequently used to characterize receptor coordination, pathway interactions, and the temporal dynamics of dual-receptor activation under controlled conditions, serving as a research tool rather than representing a single mechanism.
Survodutide Research Applications
Survodutide is investigated across preclinical and translational studies as a dual-receptor peptide for exploring glucagon and incretin receptor biology. The observations below derive from biochemical studies, cell-based assays, and animal models, and should be interpreted within their respective settings.
Dual-Receptor Signaling & Comparative Pharmacology
A primary application is investigating coordinated signaling across glucagon and GLP-1 receptor systems, receptor cross-talk, signaling integration, and downstream responses when both receptors are engaged.
Survodutide is also used in comparative research evaluating single, dual, and tri-receptor peptide designs, examining differences in binding characteristics, signaling duration, and pharmacological behavior without establishing clinical superiority.
Hepatic, Metabolic & Translational Models
Because glucagon receptors are highly expressed in the liver, researchers use Survodutide to study hepatic lipid handling and energy-expenditure signaling in animal models, and to bridge mechanistic findings with broader investigations of peptide pharmacology. These studies aim to improve understanding of receptor-mediated communication rather than to establish physiological or therapeutic effects.
Laboratory Safety & Handling (Research Use Only)
Survodutide is a synthetic, lyophilized research peptide for laboratory investigation only. It should be handled by qualified personnel in controlled environments, in accordance with institutional policies, laboratory safety procedures, and applicable regulations. As an investigational material, laboratories should implement practices that prioritize material integrity, traceability, and reproducibility.
Handling & Storage Guidelines
Follow institutional SOPs, chemical hygiene plans, and approved protocols; wear appropriate PPE (lab coat, gloves, eye protection); and use engineering controls where required. Record lot numbers, storage conditions, and handling activities, and retain Certificates of Analysis and batch documentation to support traceability and audit readiness.
Store material under the conditions specified in product documentation, protected from excessive heat, moisture, and direct light. Maintain consistent conditions throughout the study period and monitor storage records as part of quality assurance. Consistent handling and documentation support reliable, reproducible outcomes.
Certificate of Analysis & Quality Assurance
Each Survodutide batch ships with a third-party-verified Certificate of Analysis, providing transparent, research-grade quality control. The CoA includes a purity assessment (HPLC / reverse-phase chromatography), mass-spectrometry identity confirmation, and lot number, testing date, and method documentation.
Researchers may request sample CoAs (PDF) ahead of purchase to confirm testing parameters, analytical methods, and batch consistency, and are encouraged to perform independent verification.
Research Use Only
