Cagrilintide is a synthetic, long-acting amylin analog engineered for prolonged receptor engagement through acylation. For research teams studying metabolic signaling, it provides a tool for investigating amylin (AMY) and calcitonin (CT) receptor pharmacology distinct from incretin-based compounds. Puritide Research supplies Cagrilintide as a high-purity, research-use-only material, synthesized for in vitro and animal-model work and backed by third-party-verified certificates of analysis so your data rests on consistent, documented quality.
Product Specifications
- Application
- Amylin / calcitonin receptor signaling research (long-acting amylin analog)
- Appearance
- Solid, white lyophilized powder in a sealed glass vial
- Chemical Formula
- C194H312N54O59S2
- PubChem SID
- 171397054
- CAS Number
- 1415456-99-3
- Molecular Weight
- ~4409.01 g/mol
- Synonyms
- Cagrilintide, AM833, NNC0174-0833, long-acting amylin analog, acylated amylin analogue
- Storage
- Store at ≤25°C, sealed, away from heat, light, and moisture. For extended storage, keep lyophilized and refrigerated or frozen.
What Is Cagrilintide?
Cagrilintide (AM833) is a synthetic analog of amylin, a peptide hormone co-secreted with insulin from pancreatic beta cells. It is engineered as a long-acting molecule through acylation, the attachment of a fatty-acid chain that promotes reversible albumin binding, giving it sustained persistence relative to native amylin.
In experimental settings, Cagrilintide is used to study signaling at the amylin and calcitonin receptor systems, which it engages as a non-selective agonist. Its extended-duration design separates it from the native hormone and from short-acting analogs, letting researchers examine sustained receptor engagement in controlled models.
Present understanding derives from in vitro assays, animal models, and clinical research. Findings should be interpreted within their experimental context and not treated as established clinical outcomes. Puritide Research supplies Cagrilintide strictly for laboratory use; it is not approved for human or veterinary application.
Cagrilintide Mechanism of Action (Research Only)
Cagrilintide is studied for its engagement of the amylin and calcitonin receptor systems as a long-acting amylin analog. The mechanisms below reflect observations from biochemical assays, cell-culture studies, and animal models, and should be read strictly in a research context.
Amylin & Calcitonin Receptor Signaling
Amylin signaling occurs through a family of receptors formed when the calcitonin receptor (CTR) associates with receptor activity-modifying proteins (RAMPs). Cagrilintide is investigated as a non-selective agonist across amylin receptor subtypes and the calcitonin receptor, allowing researchers to study signaling that native, short-lived amylin cannot sustain in vitro.
This receptor profile is a distinguishing research feature, letting investigators examine amylinergic signaling pathways and their downstream messengers within controlled model systems.
Acylation & Sustained Engagement
The molecule incorporates a lipidation modification that promotes reversible albumin binding. In experimental systems this feature is associated with prolonged molecular stability and sustained receptor engagement, making Cagrilintide a useful model for studies of time-dependent amylin-receptor signaling and comparative pharmacology against native amylin.
Because of its extended persistence, Cagrilintide is frequently studied alongside incretin-based compounds to characterize how amylinergic and incretin signaling systems behave when engaged in parallel within the same experimental framework.
Cagrilintide Research Applications
Cagrilintide is investigated across preclinical and translational studies as a long-acting amylin analog for exploring amylin and calcitonin receptor biology. The observations below derive from biochemical studies, cell-based assays, and animal models, and should be interpreted within their respective settings.
Amylinergic Signaling & Metabolic Models
A primary application is investigating amylin and calcitonin receptor signaling, receptor engagement, downstream messenger systems, and the dynamics of sustained agonism in model systems. Researchers use it to study amylinergic pathways under controlled conditions.
Cagrilintide is also used in metabolic-model research examining energy-balance signaling networks, characterizing how amylin-receptor activity contributes to the regulation of feeding and metabolic pathways in animal models without establishing clinical outcomes.
Combination & Comparative Pharmacology
Cagrilintide is frequently studied in combination with GLP-1 receptor agonists such as semaglutide, letting researchers examine how amylinergic and incretin signaling interact when engaged together. It is also used in comparative research contrasting native amylin, short-acting analogs, and long-acting designs, characterizing differences in signaling duration and receptor behavior rather than establishing therapeutic superiority.
Comparison
| Parameter | Cagrilintide | Semaglutide |
|---|
| Molecular classification | Synthetic long-acting amylin analog | Synthetic GLP-1 receptor agonist |
| Primary receptor targets | Amylin receptors (AMY) & calcitonin receptor (CTR) | GLP-1 receptor (GLP-1R) |
| Native hormone basis | Amylin | Glucagon-like peptide-1 |
| Primary research focus | Amylinergic receptor signaling | GLP-1 receptor pharmacology |
| Duration strategy | Acylation / albumin binding | Acylation / albumin binding |
Laboratory Safety & Handling (Research Use Only)
Cagrilintide is a synthetic, lyophilized research peptide for laboratory investigation only. It should be handled by qualified personnel in controlled environments, in accordance with institutional policies, laboratory safety procedures, and applicable regulations. As a research material, laboratories should implement practices that prioritize material integrity, traceability, and reproducibility.
Handling & Storage Guidelines
Follow institutional SOPs, chemical hygiene plans, and approved protocols; wear appropriate PPE (lab coat, gloves, eye protection); and use engineering controls where required. Record lot numbers, storage conditions, and handling activities, and retain Certificates of Analysis and batch documentation to support traceability and audit readiness.
Store material under the conditions specified in product documentation, protected from excessive heat, moisture, and direct light. Reconstituted peptide should be kept refrigerated and used within the timeframe indicated by your protocol. Consistent handling and documentation support reliable, reproducible outcomes.
Certificate of Analysis & Quality Assurance
Each Cagrilintide batch ships with a third-party-verified Certificate of Analysis, providing transparent, research-grade quality control. The CoA includes a purity assessment (HPLC / reverse-phase chromatography), mass-spectrometry identity confirmation, and lot number, testing date, and method documentation.
Researchers may request sample CoAs (PDF) ahead of purchase to confirm testing parameters, analytical methods, and batch consistency, and are encouraged to perform independent verification.
Research Use Only
