Adipotide (FTPP) is a synthetic peptidomimetic studied as a targeted anti-adipose research tool, combining a vasculature-homing motif with a pro-apoptotic domain. For teams investigating white-adipose-tissue vasculature, targeted cell ablation, and metabolic models, it offers a defined two-part construct with a well-characterized design rationale. Puritide Research supplies Adipotide as a high-purity, research-use-only material, prepared for in vitro and animal-model work and backed by third-party-verified certificates of analysis so your data rests on consistent, documented quality.
Product Specifications
- Application
- Targeted adipose-vasculature and metabolic research
- Appearance
- Solid, white lyophilized powder in a sealed glass vial
- Chemical Formula
- C111H206N36O28S2
- PubChem SID
- 163360068
- CAS Number
- 859216-15-2
- Molecular Weight
- ~2557.2 g/mol
- Synonyms
- Adipotide, FTPP, Prohibitin-targeting peptide-1, CKGGRAKDC-GG-D(KLAKLAK)2
- Storage
- Store at ≤25°C, sealed, away from heat, light, and moisture. For extended storage, keep lyophilized and refrigerated or frozen.
What Is Adipotide?
Adipotide (FTPP, prohibitin-targeting peptide-1) is a synthetic peptidomimetic composed of two functional parts: a homing sequence (CKGGRAKDC) that binds prohibitin on the vasculature of white adipose tissue, and a pro-apoptotic domain (a D-amino-acid (KLAKLAK)2 sequence) linked by a short spacer. This modular design directs a cell-disrupting payload specifically toward fat-tissue blood vessels.
In experimental settings, Adipotide is used to study targeted ablation of adipose vasculature and its metabolic consequences. By selectively affecting the blood supply of white fat in research models, investigators can examine how disrupting adipose vascular support influences fat mass and metabolic parameters.
Present understanding derives from cell-culture assays and animal models, including rodent and non-human-primate studies reported in the literature. Findings should be interpreted within their experimental context and not treated as established clinical outcomes. Puritide Research supplies Adipotide strictly for laboratory use; it is not approved for human or veterinary application.
Adipotide Mechanism of Action (Research Only)
Adipotide is studied as a targeted peptidomimetic that couples an adipose-vasculature homing motif to a pro-apoptotic domain. The mechanisms below reflect observations from cell-culture studies and animal models, and should be read strictly in a research context.
Prohibitin-Targeted Homing
The CKGGRAKDC portion of Adipotide binds prohibitin, a marker expressed on the endothelial vasculature that supplies white adipose tissue. In research models this homing function is studied as a means of directing the construct selectively to fat-tissue blood vessels rather than to other tissues, providing a model of targeted delivery.
Pro-Apoptotic Domain and Vascular Ablation
Once localized, the (KLAKLAK)2 domain is investigated for its association with disruption of mitochondrial membranes and induction of apoptosis in the targeted endothelial cells. In research models this is linked to reduced vascular support of white adipose tissue.
By removing the blood supply that sustains fat tissue, Adipotide is studied for associations with decreased fat mass and altered metabolic parameters in animal models. These observations characterize the compound as a targeted research tool rather than establishing any physiological or therapeutic outcome.
Adipotide Research Applications
Adipotide is investigated across preclinical studies as a targeted peptidomimetic for exploring adipose-vasculature biology and metabolism. The observations below derive from cell-based assays and animal models, and should be interpreted within their respective settings.
Adipose-Vasculature and Obesity Models
A primary application is the study of white-adipose-tissue vasculature, where Adipotide is used in rodent and non-human-primate obesity models to examine targeted vascular ablation and its effects on fat mass. Researchers use these systems to characterize the relationship between adipose blood supply and metabolic phenotype.
It is also studied for associations with insulin sensitivity and metabolic parameters in these models, without establishing therapeutic outcomes.
Targeted Delivery and Peptidomimetic Design
As a two-part homing-plus-payload construct, Adipotide serves as a reference example in targeted-delivery research, supporting studies of tissue-selective homing motifs and pro-apoptotic domains. These studies aim to improve understanding of targeted peptidomimetic design rather than to establish physiological effects.
Laboratory Safety & Handling (Research Use Only)
Adipotide is a synthetic, lyophilized research peptidomimetic for laboratory investigation only. It should be handled by qualified personnel in controlled environments, in accordance with institutional policies, laboratory safety procedures, and applicable regulations. As an investigational material with a cytotoxic pro-apoptotic domain, laboratories should implement practices that prioritize careful handling, material integrity, traceability, and reproducibility.
Handling & Storage Guidelines
Follow institutional SOPs, chemical hygiene plans, and approved protocols; wear appropriate PPE (lab coat, gloves, eye protection); and use engineering controls where required. Record lot numbers, storage conditions, and handling activities, and retain Certificates of Analysis and batch documentation to support traceability and audit readiness.
Store material under the conditions specified in product documentation, protected from excessive heat, moisture, and direct light. Maintain consistent conditions throughout the study period and monitor storage records as part of quality assurance. Consistent handling and documentation support reliable, reproducible outcomes.
Certificate of Analysis & Quality Assurance
Each Adipotide batch ships with a third-party-verified Certificate of Analysis, providing transparent, research-grade quality control. The CoA includes a purity assessment (HPLC / reverse-phase chromatography), mass-spectrometry identity confirmation, and lot number, testing date, and method documentation.
Researchers may request sample CoAs (PDF) ahead of purchase to confirm testing parameters, analytical methods, and batch consistency, and are encouraged to perform independent verification.
Research Use Only
