Mazdutide is a synthetic dual-agonist peptide that engages both the glucagon-like peptide-1 receptor (GLP-1R) and the glucagon receptor (GCGR). Derived from the gut hormone oxyntomodulin, it offers researchers a distinct dual-receptor pharmacological profile for studying incretin and glucagon signaling. Puritide Research supplies Mazdutide as a high-purity, research-use-only material, synthesized for in vitro and animal-model work and backed by third-party-verified certificates of analysis so your data rests on consistent, documented quality.
Product Specifications
- Application
- Dual-agonist metabolic pathway research (GLP-1 / glucagon)
- Appearance
- Solid, white lyophilized powder in a sealed glass vial
- Chemical Formula
- C210H322N46O67
- CAS Number
- 2259884-03-0
- Molecular Weight
- ~4563.1 g/mol
- Synonyms
- Mazdutide, IBI362, LY3305677, OXM-3, oxyntomodulin analog, GLP-1R/GCGR dual agonist
- Storage
- Store at ≤25°C, sealed, away from heat, light, and moisture. For extended storage, keep lyophilized and refrigerated or frozen.
What Is Mazdutide?
Mazdutide (IBI362 / LY3305677) is a synthetic peptide derived from the naturally occurring gut hormone oxyntomodulin. It is engineered as a dual agonist that interacts with two receptor systems: the glucagon-like peptide-1 receptor (GLP-1R) and the glucagon receptor (GCGR).
In experimental settings, Mazdutide is used to study coordinated incretin and glucagon receptor signaling, receptor pharmacology, and downstream intracellular cascades. Its dual-receptor design distinguishes it from single-receptor GLP-1 analogs and from tri-agonist peptides, letting researchers examine two-pathway interactions within controlled models.
Present understanding derives from in vitro assays, animal models, and ongoing clinical research. Findings should be interpreted within their experimental context and not treated as established clinical outcomes. Puritide Research supplies Mazdutide strictly for laboratory use; it is not approved for human or veterinary application.
Mazdutide Mechanism of Action (Research Only)
Mazdutide is studied for its ability to engage two receptors involved in incretin and glucagon signaling, GLP-1R and GCGR. The mechanisms below reflect observations from biochemical assays, cell-culture studies, and animal models, and should be read strictly in a research context.
Structural Basis
Mazdutide is a synthetic oxyntomodulin-based peptide incorporating a lipid modification that promotes reversible albumin binding. In experimental systems this feature is associated with prolonged molecular stability and sustained receptor engagement, making the compound useful for studies of time-dependent receptor signaling.
GLP-1 and Glucagon Receptor Signaling
One focus of Mazdutide research is GLP-1 receptor signaling, the intracellular events initiated after receptor engagement. Within the dual-receptor framework, GLP-1R activity is examined alongside GCGR rather than in isolation.
GCGR interaction is investigated for its contribution to receptor cross-talk and intracellular signaling dynamics when both receptors are engaged simultaneously. Because Mazdutide engages both systems in the same model, it is used to characterize receptor coordination and the temporal dynamics of dual-receptor activation under controlled conditions.
Mazdutide Research Applications
Mazdutide is investigated across preclinical and translational studies as a dual-receptor peptide for exploring incretin and glucagon receptor biology. The observations below derive from biochemical studies, cell-based assays, and animal models, and should be interpreted within their respective settings.
Dual-Receptor Signaling & Comparative Pharmacology
A primary application is investigating coordinated signaling across GLP-1 and glucagon receptor systems, receptor cross-talk, signaling integration, and downstream responses when both receptors are engaged at once.
Mazdutide is also used in comparative research evaluating single, dual, and tri-receptor peptide designs, examining differences in binding characteristics, signaling duration, and pharmacological behavior without establishing clinical superiority.
Endocrine and Metabolic Models
Researchers use Mazdutide to study endocrine signaling networks involving incretin and glucagon pathways, including energy expenditure and metabolic markers in model systems. These studies aim to improve understanding of receptor-mediated communication rather than to establish physiological or therapeutic effects.
Laboratory Safety & Handling (Research Use Only)
Mazdutide is a synthetic, lyophilized research peptide for laboratory investigation only. It should be handled by qualified personnel in controlled environments, in accordance with institutional policies, laboratory safety procedures, and applicable regulations. As an investigational material, laboratories should implement practices that prioritize material integrity, traceability, and reproducibility.
Handling & Storage Guidelines
Follow institutional SOPs, chemical hygiene plans, and approved protocols; wear appropriate PPE (lab coat, gloves, eye protection); and use engineering controls where required. Record lot numbers, storage conditions, and handling activities, and retain Certificates of Analysis and batch documentation to support traceability and audit readiness.
Store material under the conditions specified in product documentation, protected from excessive heat, moisture, and direct light. Maintain consistent conditions throughout the study period and monitor storage records as part of quality assurance.
Certificate of Analysis & Quality Assurance
Each Mazdutide batch ships with a third-party-verified Certificate of Analysis, providing transparent, research-grade quality control. The CoA includes a purity assessment (HPLC / reverse-phase chromatography), mass-spectrometry identity confirmation, and lot number, testing date, and method documentation.
Researchers may request sample CoAs (PDF) ahead of purchase to confirm testing parameters, analytical methods, and batch consistency, and are encouraged to perform independent verification.
Research Use Only
