SNAP-8, also known as Acetyl Octapeptide-3, is a synthetic eight-amino-acid peptide developed as an extended analog of the acetyl hexapeptide family. It is studied as a model compound for neuromuscular signaling at the synapse, particularly the SNARE-complex machinery involved in vesicle fusion. Puritide Research supplies SNAP-8 as a high-purity, research-use-only material, synthesized for in vitro work and backed by third-party-verified certificates of analysis so your data rests on consistent, documented quality.
Product Specifications
- Application
- SNARE-complex and neuromuscular-signaling research
- Appearance
- Solid, white lyophilized powder in a sealed glass vial
- Chemical Formula
- C41H70N16O16S
- CAS Number
- 868844-74-0
- Molecular Weight
- ~1075.17 g/mol
- Synonyms
- SNAP-8, Acetyl Octapeptide-3, Acetyl Glutamyl Octapeptide-3, Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2
- Storage
- Store at ≤25°C, sealed, away from heat, light, and moisture. For extended storage, keep lyophilized and refrigerated or frozen.
What Is SNAP-8?
SNAP-8 (Acetyl Octapeptide-3) is a synthetic octapeptide with the sequence Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2. It features an N-terminal acetyl group and a C-terminal amide and is designed as a longer analog of the acetyl hexapeptide series, extending the peptide chain that mimics a portion of the SNAP-25 protein.
In experimental settings, SNAP-8 is studied as a research probe for the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex, which mediates synaptic vesicle docking and neurotransmitter release. The peptide's sequence corresponds to a region of SNAP-25 involved in this molecular machinery.
Present understanding derives from in vitro and biochemical studies. Findings should be interpreted within their experimental context and not treated as established clinical outcomes. Puritide Research supplies SNAP-8 strictly for laboratory use; it is not approved here for human, veterinary, or cosmetic application.
SNAP-8 Mechanism of Action (Research Only)
SNAP-8 is studied for its structural correspondence to a segment of the SNAP-25 protein and its proposed interaction with the SNARE-complex assembly. The mechanisms below reflect observations from biochemical and cell-based studies and should be read strictly in a research context.
SNARE-Complex Modeling
The SNARE complex is a protein assembly that drives the fusion of synaptic vesicles with the presynaptic membrane, enabling neurotransmitter release. Because SNAP-8's sequence mirrors a portion of SNAP-25, one of the core SNARE proteins, researchers use it as a peptide probe to investigate how fragments of this region influence complex assembly in model systems.
In experimental assays, investigators examine whether the peptide competes with native SNAP-25 during SNARE assembly, using the compound to characterize sequence-dependent contributions to vesicle-fusion machinery under controlled conditions.
Structural Basis
The N-terminal acetylation and C-terminal amidation of SNAP-8 confer stability and mimic the capped ends of a protein fragment. Structure-activity research uses the octapeptide, alongside shorter hexapeptide analogs, to study how peptide length and terminal modifications affect binding behavior in SNARE-modeling assays.
SNAP-8 Research Applications
SNAP-8 is investigated as a synthetic peptide probe in neuromuscular-signaling and biochemistry studies. The observations below derive from biochemical and cell-based assays and should be interpreted within their respective settings.
Vesicle-Fusion & Synaptic Signaling Models
A primary application is investigating SNARE-complex assembly and synaptic vesicle-fusion mechanics in cell-free and cell-based models. Researchers use SNAP-8 as a sequence-defined probe to examine how SNAP-25-derived fragments interact with the vesicle-fusion machinery.
SNAP-8 is also used in comparative research alongside shorter acetyl hexapeptide analogs, examining how chain length influences binding behavior and assay readouts without establishing physiological outcomes.
Peptide Chemistry & Formulation Research
Because of its defined, stable structure, SNAP-8 is used in peptide-chemistry and formulation-science studies as a model hydrophilic octapeptide, supporting method development in analytics, stability testing, and delivery-model research. These studies aim to advance methodological understanding rather than to establish therapeutic or cosmetic effects.
Laboratory Safety & Handling (Research Use Only)
SNAP-8 is a synthetic, lyophilized research peptide for laboratory investigation only. It should be handled by qualified personnel in controlled environments, in accordance with institutional policies, laboratory safety procedures, and applicable regulations. As a research material, laboratories should implement practices that prioritize material integrity, traceability, and reproducibility.
Handling & Storage Guidelines
Follow institutional SOPs, chemical hygiene plans, and approved protocols; wear appropriate PPE (lab coat, gloves, eye protection); and use engineering controls where required. Record lot numbers, storage conditions, and handling activities, and retain Certificates of Analysis and batch documentation to support traceability and audit readiness. Note that the methionine residue can be sensitive to oxidation, so limit exposure to air and light when handling working solutions.
Store material under the conditions specified in product documentation, protected from excessive heat, moisture, and direct light. Maintain consistent conditions throughout the study period and monitor storage records as part of quality assurance. Consistent handling and documentation support reliable, reproducible outcomes.
Certificate of Analysis & Quality Assurance
Each SNAP-8 batch ships with a third-party-verified Certificate of Analysis, providing transparent, research-grade quality control. The CoA includes a purity assessment (HPLC / reverse-phase chromatography), mass-spectrometry identity confirmation, and lot number, testing date, and method documentation.
Researchers may request sample CoAs (PDF) ahead of purchase to confirm testing parameters, analytical methods, and batch consistency, and are encouraged to perform independent verification.
Research Use Only
