The Selank/Semax Blend combines two synthetic heptapeptides, Selank, a tuftsin analog, and Semax, an ACTH(4-10) analog, in a single vial for research teams that want to study both neuroactive peptides in parallel. Each compound carries its own well-characterized preclinical literature, and the blend format supports comparative and combined-exposure experimental designs. Puritide Research supplies this blend as a high-purity, research-use-only material, synthesized for in vitro and animal-model work and backed by third-party-verified certificates of analysis so your data rests on consistent, documented quality.
Available Sizes
- ›Selank/Semax Blend 10mg (5+5) Vial
- ›Selank/Semax Blend 20mg (10+10) Vial
Product Specifications
- Application
- Combined neuropeptide, anxiolytic, and neuroprotective pathway research
- Appearance
- Solid, white lyophilized powder in a sealed glass vial
- Chemical Formula
- Selank: C33H57N11O9 / Semax: C37H51N9O10S
- CAS Number
- Selank: 129954-34-3 / Semax: 80714-61-0
- Molecular Weight
- Selank: ~751.88 g/mol / Semax: ~813.93 g/mol
- Synonyms
- Selank (TP-7, tuftsin analog, TKPRPGP) + Semax (ACTH(4-10) analog, MEHFPGP)
- Storage
- Store at ≤25°C, sealed, away from heat, light, and moisture. For extended storage, keep lyophilized and refrigerated or frozen.
What Is the Selank/Semax Blend?
The Selank/Semax Blend is a co-formulated preparation of two distinct synthetic heptapeptides supplied in a defined ratio (5+5 or 10+10). Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is a stabilized analog of the tuftsin tetrapeptide, and Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is an analog of the ACTH(4-10) fragment. Both were developed at the Institute of Molecular Genetics of the Russian Academy of Sciences and share a Pro-Gly-Pro C-terminal motif associated with enzymatic stability.
In experimental settings, the blend is studied to examine the two peptides in combination, for instance, comparing anxiolytic-related signaling associated with Selank against neurotrophic and neuroprotective signaling associated with Semax within the same model system. This supports combined-exposure and comparative research designs.
Present understanding of each component derives from in vitro assays and animal models, together with clinical research conducted primarily in Russia. Findings should be interpreted within their experimental context and not treated as established outcomes. Puritide Research supplies this blend strictly for laboratory use; it is not approved for human or veterinary application.
Selank/Semax Blend Mechanism of Action (Research Only)
The blend brings together two peptides with distinct but complementary research profiles. The mechanisms below reflect observations for each component from biochemical assays, cell-culture studies, and animal models, and should be read strictly in a research context.
Selank Component, GABAergic & Neuroimmune Signaling
Selank is studied for modulation of GABAergic neurotransmission and neuroimmune pathways. In cell models it has been reported to affect the expression of genes involved in GABAergic signaling, and its tuftsin lineage makes it a subject of neuroimmune and cytokine-related investigation. Within the blend, Selank contributes an anxiolytic-pathway and immune-signaling dimension to combined studies.
Semax Component, BDNF/TrkB & Neuroprotective Signaling
Semax is studied for its influence on the BDNF/TrkB neurotrophic system and on neuroprotective pathways in ischemia and hypoxia models. Within the blend, Semax contributes a neurotrophic and neuroprotective dimension, allowing researchers to examine how the two peptides' signaling profiles interact or diverge under identical conditions.
Together, the components let researchers characterize multi-system neuropeptide activity in a single experimental design rather than testing each peptide in isolation.
Selank/Semax Blend Research Applications
The blend is investigated in preclinical studies that benefit from evaluating both peptides together. The observations below derive from biochemical studies, cell-based assays, and animal models for the individual components, and should be interpreted within their respective settings.
Combined & Comparative Neuropeptide Studies
A primary application is combined-exposure research, where investigators study the joint or interacting effects of an anxiolytic-associated peptide (Selank) and a neurotrophic-associated peptide (Semax) within one model.
The format also supports comparative studies, letting researchers evaluate differences in signaling profile, gene expression, and behavioral endpoints between the two peptides under matched conditions.
Neuroprotective & Behavioral Pathway Models
Researchers use the blend in behavioral and neuroprotection-related paradigms to explore how combined neuropeptide exposure influences stress-related, neurotrophic, and neuroimmune endpoints. These studies aim to improve mechanistic understanding rather than to establish physiological or therapeutic effects.
Laboratory Safety & Handling (Research Use Only)
The Selank/Semax Blend is a synthetic, lyophilized research preparation for laboratory investigation only. It should be handled by qualified personnel in controlled environments, in accordance with institutional policies, laboratory safety procedures, and applicable regulations. As a research material, laboratories should implement practices that prioritize material integrity, traceability, and reproducibility.
Handling & Storage Guidelines
Follow institutional SOPs, chemical hygiene plans, and approved protocols; wear appropriate PPE (lab coat, gloves, eye protection); and use engineering controls where required. Record lot numbers, storage conditions, and handling activities, and retain Certificates of Analysis and batch documentation to support traceability and audit readiness.
Store material under the conditions specified in product documentation, protected from excessive heat, moisture, and direct light. Maintain consistent conditions throughout the study period and monitor storage records as part of quality assurance. Consistent handling and documentation support reliable, reproducible outcomes.
Certificate of Analysis & Quality Assurance
Each Selank/Semax Blend batch ships with a third-party-verified Certificate of Analysis, providing transparent, research-grade quality control. The CoA includes a purity assessment (HPLC / reverse-phase chromatography), mass-spectrometry identity confirmation for each component, and lot number, testing date, and method documentation.
Researchers may request sample CoAs (PDF) ahead of purchase to confirm testing parameters, analytical methods, blend ratio, and batch consistency, and are encouraged to perform independent verification.
Research Use Only
