Selank is a synthetic heptapeptide derived from the endogenous immunomodulatory tetrapeptide tuftsin, extended with a Pro-Gly-Pro motif that improves enzymatic stability. For research teams investigating neuropeptide signaling, anxiolytic pathways, and neuroimmune interactions, it offers a well-characterized tool compound with an extensive Russian preclinical literature. Puritide Research supplies Selank as a high-purity, research-use-only material, synthesized for in vitro and animal-model work and backed by third-party-verified certificates of analysis so your data rests on consistent, documented quality.
Product Specifications
- Application
- Neuropeptide, anxiolytic pathway, and neuroimmune signaling research
- Appearance
- Solid, white lyophilized powder in a sealed glass vial
- Chemical Formula
- C33H57N11O9
- PubChem SID
- 11765600
- CAS Number
- 129954-34-3
- Molecular Weight
- ~751.88 g/mol
- Synonyms
- Selank, TP-7, Tuftsin analog, Heptapeptide Selank, Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP)
- Storage
- Store at ≤25°C, sealed, away from heat, light, and moisture. For extended storage, keep lyophilized and refrigerated or frozen.
What Is Selank?
Selank is a synthetic heptapeptide with the amino acid sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP). It was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences as a stabilized analog of tuftsin, a naturally occurring tetrapeptide (Thr-Lys-Pro-Arg) with immunomodulatory activity. The added C-terminal Pro-Gly-Pro sequence is intended to slow enzymatic degradation and extend the molecule's stability relative to the parent peptide.
In experimental settings, Selank is studied for its influence on neuropeptide signaling, GABAergic and monoaminergic systems, and neuroimmune pathways. Researchers use it to explore anxiolytic-related mechanisms, gene-expression changes, and peptide pharmacology within controlled cell-culture and animal models.
Present understanding derives from in vitro assays and animal models, together with clinical research conducted primarily in Russia. Findings should be interpreted within their experimental context and not treated as established outcomes. Puritide Research supplies Selank strictly for laboratory use; it is not approved for human or veterinary application.
Selank Mechanism of Action (Research Only)
Selank is investigated for its ability to influence multiple neurochemical systems rather than a single receptor target. The mechanisms below reflect observations from biochemical assays, cell-culture studies, and animal models, and should be read strictly in a research context.
Structural Basis & Stability
Selank's heptapeptide sequence extends the tuftsin core with a Pro-Gly-Pro motif that is associated in the literature with resistance to carboxypeptidase and prolyl endopeptidase cleavage. In experimental systems this feature is linked to prolonged molecular stability, which researchers examine when studying peptide half-life and central penetration in model systems.
GABAergic, Monoaminergic & Neuroimmune Signaling
A primary focus of Selank research is its modulation of GABAergic neurotransmission. In cell models, Selank has been reported to affect the expression of genes involved in GABAergic signaling, and researchers use it to probe how tuftsin-derived peptides interact with inhibitory neurotransmitter systems.
Selank is also studied for effects on monoamine turnover and on the expression of neurotrophic and immune-related mediators. Because it derives from tuftsin, its neuroimmune activity, including reported influence on cytokine and interferon-related pathways, is a recurring subject of investigation.
Across these studies, Selank serves as a research tool for characterizing multi-system neuropeptide activity under controlled conditions rather than representing a single, defined mechanism.
Selank Research Applications
Selank is investigated across preclinical and translational studies as a neuroactive peptide for exploring anxiolytic mechanisms and neuroimmune biology. The observations below derive from biochemical studies, cell-based assays, and animal models, and should be interpreted within their respective settings.
Anxiolytic & Behavioral Pathway Models
A leading application is the study of anxiolytic-related signaling in animal models, where Selank is used to examine behavioral and neurochemical endpoints without the sedative profile associated with classical benzodiazepine tool compounds.
Researchers also employ Selank in comparative studies of peptide anxiolytics, evaluating gene-expression changes in brain and peripheral tissue to characterize how the compound engages inhibitory and stress-related pathways.
Neuroimmune & Peptide Pharmacology Studies
As a tuftsin-derived peptide, Selank is used to investigate neuroimmune signaling, including effects on cytokine expression and immune-cell activity in controlled models. It also supports broader peptide-pharmacology work exploring stability, delivery, and structure-activity relationships. These studies aim to improve mechanistic understanding rather than to establish physiological or therapeutic effects.
Laboratory Safety & Handling (Research Use Only)
Selank is a synthetic, lyophilized research peptide for laboratory investigation only. It should be handled by qualified personnel in controlled environments, in accordance with institutional policies, laboratory safety procedures, and applicable regulations. As a research material, laboratories should implement practices that prioritize material integrity, traceability, and reproducibility.
Handling & Storage Guidelines
Follow institutional SOPs, chemical hygiene plans, and approved protocols; wear appropriate PPE (lab coat, gloves, eye protection); and use engineering controls where required. Record lot numbers, storage conditions, and handling activities, and retain Certificates of Analysis and batch documentation to support traceability and audit readiness.
Store material under the conditions specified in product documentation, protected from excessive heat, moisture, and direct light. Maintain consistent conditions throughout the study period and monitor storage records as part of quality assurance. Consistent handling and documentation support reliable, reproducible outcomes.
Certificate of Analysis & Quality Assurance
Each Selank batch ships with a third-party-verified Certificate of Analysis, providing transparent, research-grade quality control. The CoA includes a purity assessment (HPLC / reverse-phase chromatography), mass-spectrometry identity confirmation, and lot number, testing date, and method documentation.
Researchers may request sample CoAs (PDF) ahead of purchase to confirm testing parameters, analytical methods, and batch consistency, and are encouraged to perform independent verification.
Research Use Only
