Matrixyl is the trade name for palmitoyl pentapeptide-4 (Pal-KTTKS), a lipidated matrikine peptide widely studied in dermatological and extracellular-matrix research. Pairing a five-residue collagen-fragment sequence with a palmitic acid chain, it is investigated for its association with collagen and matrix-protein signaling in skin model systems. Puritide Research supplies Matrixyl as a high-purity, research-use-only material, prepared for in vitro and topical-model work and backed by third-party-verified certificates of analysis so your data rests on consistent, documented quality.
Product Specifications
- Application
- Dermatological and extracellular-matrix (collagen) research
- Appearance
- Supplied as a reconstituted solution in a sealed vial
- Chemical Formula
- C39H75N7O10
- PubChem SID
- 9959949
- CAS Number
- 214047-00-4
- Molecular Weight
- ~802.07 g/mol
- Synonyms
- Matrixyl, Palmitoyl pentapeptide-4, Pal-KTTKS, palmitoyl-lysine-threonine-threonine-lysine-serine, matrikine
- Storage
- Store at ≤25°C, sealed, away from heat, light, and moisture. For extended storage, keep refrigerated; avoid repeated temperature cycling.
What Is Matrixyl?
Matrixyl (palmitoyl pentapeptide-4) is a synthetic peptide consisting of the amino acid sequence Lys-Thr-Thr-Lys-Ser (KTTKS) conjugated to palmitic acid. The KTTKS fragment is derived from the propeptide region of type I collagen, and the palmitoyl chain is included to improve interaction with lipid-rich structures in skin model systems.
In experimental settings, Matrixyl is studied as a matrikine, a peptide signaling fragment, for its reported association with fibroblast activity and extracellular-matrix protein expression in cell culture and topical research models. It is a common reference compound in cosmetic-science and dermatological research.
Present understanding derives from in vitro assays and topical research models. Findings should be interpreted within their experimental context and not treated as established clinical outcomes. Puritide Research supplies Matrixyl strictly for laboratory and cosmetic-research use; it is not intended for human therapeutic application.
Matrixyl Mechanism of Action (Research Only)
Matrixyl is studied as a matrikine peptide associated with extracellular-matrix signaling in skin model systems. The mechanisms below reflect observations from biochemical assays and cell-culture studies, and should be read strictly in a research context.
Matrikine Signaling
The KTTKS sequence within Matrixyl corresponds to a fragment of type I procollagen. In research models, this matrikine is investigated for its reported ability to signal fibroblasts as though matrix turnover were occurring, prompting study of extracellular-matrix protein expression including collagen and related components.
The palmitoyl modification is examined for its role in improving the peptide's interaction with lipid structures, which supports studies of penetration and stability in topical research systems.
Fibroblast and Matrix-Protein Studies
Researchers use Matrixyl to study fibroblast responses in cell culture, including markers associated with collagen, elastin, and glycosaminoglycan production. These endpoints make it a common tool for extracellular-matrix and dermatological-model research.
Within controlled models, Matrixyl is examined for concentration- and time-dependent behavior rather than as representing a single fixed mechanism.
Matrixyl Research Applications
Matrixyl is investigated across cosmetic-science and dermatological research as a matrikine peptide for exploring extracellular-matrix biology. The observations below derive from biochemical studies and cell-based assays, and should be interpreted within their respective settings.
Extracellular-Matrix and Collagen Research
A primary application is investigating fibroblast-mediated matrix protein synthesis, collagen, elastin, and glycosaminoglycan markers in cell-culture and skin-equivalent models.
Matrixyl is also used as a reference matrikine in comparative studies evaluating peptide penetration, stability, and signaling behavior in topical research formulations.
Dermatological Model Systems
Researchers use Matrixyl in skin-model and dermatological research examining photoaging-associated markers and matrix remodeling. These studies aim to improve understanding of matrikine signaling rather than to establish clinical or therapeutic outcomes.
Laboratory Safety & Handling (Research Use Only)
Matrixyl is a synthetic research peptide for laboratory and cosmetic-research investigation only. It should be handled by qualified personnel in controlled environments, in accordance with institutional policies, laboratory safety procedures, and applicable regulations. Laboratories should implement practices that prioritize material integrity, traceability, and reproducibility.
Handling & Storage Guidelines
Follow institutional SOPs, chemical hygiene plans, and approved protocols; wear appropriate PPE (lab coat, gloves, eye protection); and use engineering controls where required. Record lot numbers, storage conditions, and handling activities, and retain Certificates of Analysis and batch documentation to support traceability and audit readiness.
Store material under the conditions specified in product documentation, protected from excessive heat, moisture, and direct light. Maintain consistent conditions throughout the study period and monitor storage records as part of quality assurance.
Certificate of Analysis & Quality Assurance
Each Matrixyl batch ships with a third-party-verified Certificate of Analysis, providing transparent, research-grade quality control. The CoA includes a purity assessment (HPLC / reverse-phase chromatography), mass-spectrometry identity confirmation, and lot number, testing date, and method documentation.
Researchers may request sample CoAs (PDF) ahead of purchase to confirm testing parameters, analytical methods, and batch consistency, and are encouraged to perform independent verification.
Research Use Only
