ARA-290 (cibinetide) is a synthetic 11-amino-acid peptide derived from the helix B region of erythropoietin, engineered to retain tissue-protective signaling while omitting the red-blood-cell-stimulating activity of the parent hormone. For research teams investigating the innate repair receptor, neuroprotection, and inflammation, it offers a defined tool for studying cytoprotective pathways in isolation. Puritide Research supplies ARA-290 as a high-purity, research-use-only material, prepared for in vitro and animal-model work and backed by third-party-verified certificates of analysis so your data rests on consistent, documented quality.
Product Specifications
- Application
- Innate repair receptor, neuroprotection, and tissue-protection research
- Appearance
- Solid, white lyophilized powder in a sealed glass vial
- Chemical Formula
- C51H84N16O21
- PubChem SID
- 91810664
- CAS Number
- 1208243-50-8
- Molecular Weight
- ~1257.3 g/mol
- Synonyms
- ARA-290, ARA290, Cibinetide, pHBSP, pyroglutamate Helix B Surface Peptide
- Storage
- Store at ≤25°C, sealed, away from heat, light, and moisture. For extended storage, keep lyophilized and refrigerated or frozen.
What Is ARA-290?
ARA-290 (cibinetide) is a synthetic peptide corresponding to a surface region of helix B of erythropoietin (EPO). It was designed to isolate the tissue-protective and anti-inflammatory signaling associated with EPO while removing the erythropoietic (red-blood-cell-stimulating) and thrombotic activities of the full hormone.
In experimental settings, ARA-290 is used to study signaling through the innate repair receptor, a heteromeric receptor complex distinct from the classical EPO receptor that mediates cytoprotection and tissue repair. This makes it a valuable probe for separating EPO's protective functions from its hematopoietic role in controlled models.
Present understanding derives from cell-culture assays, animal models, and translational research. Findings should be interpreted within their experimental context and not treated as established clinical outcomes. Puritide Research supplies ARA-290 strictly for laboratory use; it is not approved for human or veterinary application.
ARA-290 Mechanism of Action (Research Only)
ARA-290 is studied for its engagement of the innate repair receptor, a signaling complex associated with the tissue-protective arm of erythropoietin biology. The mechanisms below reflect observations from biochemical assays, cell-culture studies, and animal models, and should be read strictly in a research context.
Innate Repair Receptor Signaling
The primary research focus of ARA-290 is its interaction with the innate repair receptor, understood in the literature as a heterocomplex involving the EPO receptor and the beta-common receptor subunit. In research models, engagement of this receptor is associated with cytoprotective and anti-inflammatory signaling that is distinct from the pathway driving red-blood-cell production.
Because ARA-290 corresponds only to the helix B surface region rather than the full hormone, it does not engage the classical homodimeric EPO receptor responsible for erythropoiesis, allowing investigators to study tissue protection in isolation.
Cytoprotection and Anti-Inflammatory Pathways
In research models, ARA-290 is examined for its association with reduced inflammatory signaling and protection of tissues under stress. Investigators study downstream anti-apoptotic and anti-inflammatory cascades to characterize the tissue-protective phenotype.
It is also studied in models of nerve injury and neuropathy for its reported association with nerve-fiber preservation and repair. These observations are used to characterize innate-repair-receptor biology rather than to establish any physiological or therapeutic effect.
ARA-290 Research Applications
ARA-290 is investigated across preclinical and translational studies as an EPO-derived peptide for exploring tissue protection and inflammation. The observations below derive from biochemical studies, cell-based assays, and animal models, and should be interpreted within their respective settings.
Neuroprotection and Neuropathy Models
A primary application is the study of nerve injury and neuropathic pain models, where ARA-290 is used to examine associations with nerve-fiber preservation, regeneration, and modulation of neuropathic signaling. Small-fiber neuropathy models, including those associated with sarcoidosis and diabetes in the literature, are a notable focus.
Researchers use these systems to characterize the neuroprotective arm of innate-repair-receptor signaling without establishing clinical outcomes.
Inflammation and Tissue-Protection Studies
ARA-290 is also applied in models of inflammation and tissue stress, where investigators examine its anti-inflammatory and cytoprotective signaling. Because it separates tissue protection from erythropoiesis, it serves as a comparative probe against full-length EPO in mechanistic studies aimed at improving understanding of cytoprotective pathways.
Laboratory Safety & Handling (Research Use Only)
ARA-290 is a synthetic, lyophilized research peptide for laboratory investigation only. It should be handled by qualified personnel in controlled environments, in accordance with institutional policies, laboratory safety procedures, and applicable regulations. As an investigational material, laboratories should implement practices that prioritize material integrity, traceability, and reproducibility.
Handling & Storage Guidelines
Follow institutional SOPs, chemical hygiene plans, and approved protocols; wear appropriate PPE (lab coat, gloves, eye protection); and use engineering controls where required. Record lot numbers, storage conditions, and handling activities, and retain Certificates of Analysis and batch documentation to support traceability and audit readiness.
Store material under the conditions specified in product documentation, protected from excessive heat, moisture, and direct light. Maintain consistent conditions throughout the study period and monitor storage records as part of quality assurance. Consistent handling and documentation support reliable, reproducible outcomes.
Certificate of Analysis & Quality Assurance
Each ARA-290 batch ships with a third-party-verified Certificate of Analysis, providing transparent, research-grade quality control. The CoA includes a purity assessment (HPLC / reverse-phase chromatography), mass-spectrometry identity confirmation, and lot number, testing date, and method documentation.
Researchers may request sample CoAs (PDF) ahead of purchase to confirm testing parameters, analytical methods, and batch consistency, and are encouraged to perform independent verification.
Research Use Only
